A number of studies have demonstrated that a 1 μg dose (low-dose corticotropin [LD-ACTH] stimulation test) of corticotropin is more sensitive and specific for diagnosing primary and secondary adrenal insufficiency than the 250 μg dose of corticotropin (HD-ACTH).[30–34]. The gene discussed is POMC; the disease is Adrenal insufficiency.