ALB and neoplasm: A number of factors have been indicated as favoring or determining esophageal anastomotic leakage; the type of anastomosis, esophageal substitute, location of anastomosis (cervical or intrathoracic), whether it is a single or double layer, done manually or with stapling, the organ used in the anastomoses, the stage of the tumor, the distance from the anastomoses line to the tumoral tissue, additional radiotherapy or chemotherapy used in the treatment, the blood levels of hemoglobin and serum albumin.[14]