Our results suggest that in thyroid cells with BRAFV600E oncogenic activation the effect of sorafenib in apoptosis depends upon the balance in the levels of the anti-apoptotic proteins Mcl-1 and Bcl-2 and not in the levels of Bad and Bax (data not shown), as previously demonstrated in melanoma cells [11,35,36]. Here, MCL1 is linked to melanoma.