Similarly, one of four tested SNPs within latent transforming growth factor beta binding protein 4, LTB4P (at 41.8 Mbp) was associated (p = 0.01) with a densiometric emphysema distribution phenotype (Basal 1/3 lower lobe) [32] but not lung function [33] in 282 and 304 subjects respectively from the National Emphysema Trial. The gene discussed is LTBP4; the disease is pulmonary emphysema.