The rs2302524 (Lys220Arg) association with reduced baseline FEV1 values is of interest as this variant may be predicted to change the coding sequence of the PLAUR protein and this polymorphism has previously been associated with increased asthma risk and increased decline in FEV1 in asthma ([3], Table 4) The Lys220Arg is considered a conservative substitution, however the functional significance of this finding remains to be resolved. Here, PLAUR is linked to asthma.