In the lower BMI subset of preoperative AIS girls, there is no early and systemic skeletal evidence to suggest increased secretion of GH/IGF-I (Figure 7) According to the LHS concept, more sympathoactivation in the lower BMI subset is needed to account for curve magnitudes which are similar to those of the higher BMI subset (Figure 7). The gene discussed is IGF1; the disease is androgen insensitivity syndrome.