We suggest that in preoperative AIS girls with relatively higher BMIs, the skeletal overgrowth for age (Figure 7) [38,39,41,135-141,152] results from earlier and increased hypothalamic sensitivity of the GH/IGF axis to leptin for age leading to increased GH/IGF secretions, and possibly estrogen through other neuroendocrine axes. This evidence concerns the gene IGF1 and androgen insensitivity syndrome.