In well-nourished subjects under basal conditions, evidence for an inverse relationship of GH secretion and sympathoactivation includes: acromegaly [355,356], GH-deficiency in adults [352,353,357], GH treatment of GH-deficient adults [353], idiopathic cardiomyopathy [358], middle-aged men with high waist-hip circumference ratios with reduced GH peak size concentrations [359], ageing men, with declining GH and IGF-I secretions [360], and growth hormone transgenic mice [356]. This evidence concerns the gene IGF1 and acromegaly.