LEP and androgen insensitivity syndrome: In Fto-deficient mice the sympathoactivation associated with decreased circulating leptin levels is similar to the hypothalamic up-regulation and sympathoactivation we postulate for AIS girls, but without the skeletal overgrowth for age (see Autonomic nervous system - leptin-hypothalamic-sympathetic nervous system (LHS)-driven mechanism in health and LHS concept in AIS).