Children with exogenous obesity usually show increased height velocity [226], and their serum leptin levels are approximately five times that of normal children [227], with obese children being taller than average from 6-9 years [225], showing more advanced bone age/chronological age [227], earlier puberty and menarche [226] and no significant correlation of leptin and estradiol levels [228]. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.