APOA5 and coronary atherosclerosis: Progression of coronary atherosclerosis as determined by the change in MLD during the 2.5 years follow up, was associated with S19W SNP in APOA5. Those with the uncommon genotype (AG) had greater loss of MLD (0.25 ± 0.23 mm) over the follow up period than those with the common genotype (-0.05 ± 0.25 mm, p = 0.0048).