As Src homology 2 domain-containing phosphatase substrate 1-mutant mice have an impaired ability to clear transferred tumour cells, and lower levels of iNKT-cell cytokine production 28, and as a role for SIRPα–CD47 signalling in iNKT-cell responses to infection has yet to be established, we sought to determine whether this pathway might be involved in regulating early iNKT-cell responses to L. donovani. This evidence concerns the gene SIRPA and infection.