Although it has not been examined in this report, the defect in effector activity exhibited by CD8+ T cells generated in the liver also appears to adversely affect virus/antigen clearance since antigen (e.g. βgal enzymatic activity) elimination from the site of primary virus inoculation is delayed when the liver is the site of initial infection (J.R. Lukens, unpublished observations). This evidence concerns the gene CD8A and infection.