For instance, SEB responsive cells that produce MIP-1β could have relatively high levels of HIV DNA if those cells were CMV-specific and had responded to CMV when the subject was co-infected with HIV, while a MIP-1β non-producing cell could have virtually no history of HIV exposure if its specificity was to a pathogen which the subject had not encountered during the time of HIV infection (ie. a measles-specific cell). The gene discussed is SETBP1; the disease is HIV infectious disease.