In experimental animals and patients with osteoporosis, intermittent administration of PTH can increase bone mass by stimulating de novo bone formation.(32,34–36) However, genetic studies testing for association between polymorphisms in PTH and osteoporosis are lacking, and most of them are underpowered and show inconsistent results.(37–41) Our study found a consistent association between PTH and FN BMD in two independent white populations, thereby supporting the conclusion that PTH is an important candidate gene for BMD and osteoporosis. This evidence concerns the gene PTH and osteoporosis.