TYROBP and Leukoencephalopathy: CX3CR1 null mice show more neuronal loss and cell-autonomous microglial neurotoxicity than control mice[58] and DAP12/TYROBP [67] or associated receptor TREM2 [68] null mice show impaired phagocytic activity and enhanced inflammatory gene expression that is manifested in adult onset dementing leukoencephalopathy caused by loss of function mutations of DAP12 or TREM2.