Other affected pathways included networks of genes previously implicated in brain aging: IGF1, glucocorticoid receptor, nitric oxide and NF-kB signaling, cell cycle regulation, oxidative stress response, and pathways associated with neurodegeneration: hypoxia, Huntington's and Parkinson's diseases and amyotrophic lateral sclerosis signaling. The gene discussed is IGF1; the disease is amyotrophic lateral sclerosis.