TP53 and keloid: Previously, we showed that keloids differed from what we found in hypertrophic scars in that p53 down regulation, together with the increased ΔNp63 expression, could contribute to keloid development by means of accumulation of continuously proliferating cells [3]; we also found a significant increase in ROS (reactive oxygen species) generation in keloid fibroblasts, a phenomenon that probably relates to the inflammatory and oxidative stress status of the disease [3].