And meta-analysis on three Caucasian GWAS yielded six additional loci (JAZF1, TSPAN8-LGR5, THADA, ADAMTS9, NOTCH2-ADAM30 and CDC123-CAMK1D) associated with type 2 diabetes at genome-wide statistic significance [6]. This evidence concerns the gene LGR5 and type 2 diabetes mellitus.