And meta-analysis on three Caucasian GWAS yielded six additional loci (JAZF1, TSPAN8-LGR5, THADA, ADAMTS9, NOTCH2-ADAM30 and CDC123-CAMK1D) associated with type 2 diabetes at genome-wide statistic significance [6]. The gene discussed is NOTCH2; the disease is type 2 diabetes mellitus.