Several issues, however, still remained unclear, especially whether the exact localisation of TILs does influence their prognostic/predictive value and whether the TILs detected within ovarian carcinomas are clonally restricted and respond to a specific tumour-specific antigen, such as the candidate protein Her2/neu (Peoples et al, 1995; Goodell et al, 2008; Wiech et al, 2008). This evidence concerns the gene ERBB2 and ovarian carcinoma.