EGFR and non-small cell lung carcinoma: The EGFR TK inhibitors (TKIs, eg, erlotinib (Tarceva; OSI Pharmaceuticals, Inc, Melville, New York, USA; Genentech, Inc, South San Francisco, California, USA; and F Hoffmann-La Roche Ltd, Basel, Switzerland) and gefitinib (Iressa; AstraZeneca Pharmaceuticals, Wilmington, Delaware, USA)) are further along in clinical development for NSCLC treatment than other EGFR-targeted therapies.