Similarly, our result indicated mutation of the NF-κB motif displayed a more inhibitory effect on LMP1-increased iEκ activity compared to mutation of the AP-1 site, suggested that of NF-κB and AP-1 pathways, NF-κB pathway may play a leading role in LMP1-augmented iEκ activity in NPC cells. This evidence concerns the gene FOS and nasopharyngeal carcinoma.