At 12 h, the expression of Dentin matrix protein 1 (Dmp1) expression was up-regulated (1.9-fold) while the expression of a number of other genes was down-regulated in tibiae from these WT-OVX mice including (Cav2, − 1.7-fold) breast cancer anti-estrogen resistance 3 (Bcar3, − 1.9-fold), tumor necrosis factor receptor superfamily member 7 (Tnfrsf7, − 1.7-fold), Bcl2 associated athanogene 3 (Bag3, − 1.7-fold) and Ppargc1a (− 1.6-fold) (Fig. 3B, Table S10). The gene discussed is CAV2; the disease is breast cancer.