TXNRD3 and arthritic joint disease: For example, chemogenomics screening of the genome sequence of S. mansoni identified >20 parasite proteins for which potential drugs are available approved for other human ailments [25], and indeed for which, in the case of the schistosome thioredoxin glutathione reductase, auranofin (an anti-arthritis medication) was shown recently to exhibit potent anti-schistosomal activity [91].