LGI1 and neoplasm: Thus DaPKC might act as a ‘permissive factor’ in ept tumor growth via a positive role in endosomal trafficking upstream of ESCRT-1; in its absence a set of proteins that normally enter the endolysosomal pathway and become trapped in ept mutant endosomes are shunted toward an alternate fate that precludes their accumulation in late endosomal compartments.