VPS25 and neoplasm: Genes in this latter group have been termed ‘endocytic tumor suppressor genes’ and include rab5, syntaxin-7/avalanche (syx7/avl), erupted/tumor susceptibility gene-101 (ept/tsg101 and referred to hereafter as ept), and vps25. Each of these genes is required at distinct steps in the trafficking proteins from the apical membrane to the lysosome.