Based on these data and the dual role of TUSC2 as an immune regulator and tumor suppressor it may be suggested that TUSC2 suppression during tumor growth may be caused my multiple factors and in different cells, namely immune cells present at the site of inflammatory tumor and cancer cells where the effect of LOH is further aggravated by ROS and hypoxia (Fig. 5B). This evidence concerns the gene TUSC2 and cancer.