Looking for molecular mediators that may be relevant to lupus-like autoimmune phenotype observed in our TUSC2 knockout model [15] we noticed that at least two putative TUSC2 targets, CD24 and CD274/PD-L1/B7-H1 that regulate immunogenic T and B cells, are linked with systemic autoimmune diseases such as SLE, MS, and others [33-38]. This evidence concerns the gene CD24 and systemic lupus erythematosus.