For instance, the level of γ-H2AX increases with anindividual's age in tissue samples and with time in culture for primary cellexplants [21,37,39],which is concomitant with a parallel increase in laminopathy-induced DNA damageand the pathological changes in nuclear morphology and chromatin structures.Secondly, like in HGPS, DNA damage accumulation in healthy aging cells is notcaused by a genetic deficiency in DNA repair. Here, ZMPSTE24 is linked to laminopathy.