TheHGPS and RD laminopathies arise from deficiencies in these post-translationalmodifications of prelamin A.  All Zmpste24  enzymatic  activity is lost in individuals with RD(Zmpste24-/-);the farnesylated and carboxy-methylated prelamin A (FC-prelamin A) istoxic, especially with the absence of normal lamin A, causing perinatal death [29,30]. The gene discussed is ZMPSTE24; the disease is laminopathy.