As shown in Fig. 1A, infection of THP-1 cells with vMyxM013-KO virus significantly increased IL-1β secretion within one hour, compared to control MYXV, indicating that the vMyxM013-KO virus was uniquely unable to block the inflammasome/caspase 1-mediated response to the virus infection. The gene discussed is IL1B; the disease is viral infectious disease.