Thus, the vMyx-M013KO-induced phosphorylation of IKK and degradation of IκBα raises the possibility that deletion of MYXV-M013 from MYXV triggers change(s) in the cellular sensing and/or responses to virus infection such that it hinders the ability of the other viral gene products to prevent the degradation of IκBα. Here, NFKBIA is linked to viral infectious disease.