In the present study, we report that infection of human THP-1 monocytic cells with the vMyxM013-KO virus, unlike the parental MYXV, unexpectedly induced rapid and dramatic secretion of diverse pro-inflammatory cytokines such as TNF, IL-6 and MCP-1, all of which are regulated by NF-κB. The gene discussed is NFKB1; the disease is infection.