IFNG and Plasmodium falciparum malaria: Given the outstandingly high foreign parasite mass circulating in the blood during acute falciparum malaria and the strong induction of IFN-γ by both pre-erythrocytic stage and by blood-stage parasites, potentially leading to a very strong pro-inflammatory stimulus, there are ample reasons to analyze changes in MO numbers, phenotypes and function during malaria.