A recent analysis of 314 UK SLE families examining 68 SNPs across the HLA class II and III regions and HLA-DRB1 suggested two distinct association signals centered on DRB1*0301 and the T allele of rs419788 in intron 6 of the class III region gene SKIV2L[16]. This evidence concerns the gene HLA-DRB1 and systemic lupus erythematosus.