PRSS8 and Familial prostate cancer: To determine if prostasin re-expression in a TCC cell line could result in E-cadherin up-regulation, as we have observed previously for the human prostate cancer cell line PC-3 [8], we infected the KU-7 cell line with lentiviruses driving the expression of the wild-type human prostasin (Pro), or a serine active-site mutant variant prostasin (ProM).