We have shown that a glycosylphosphatidylinositol (GPI)-anchored epithelial extracellular membrane serine protease, prostasin/PRSS8, modulates EGFR signalling via enhancement of matriptase cleavage of the EGFR extracellular domain (ECD), and regulates SLUG and E-cadherin expression in cancer cells [7,8]. Here, CDH1 is linked to cancer.