There have been recent studies showing a role for Polo-like kinases in the hypoxic response in other organisms; a microarray study in rats identified Polo-like kinases being upregulated in a hypoxic tumor model [40], while in mice Plk3 was found to act as a regulator of hypoxia-inducible factor-1α under hypoxic conditions [41]. Here, PLK3 is linked to neoplasm.