TP53 and carcinoma: Hybridization with EBV-encoded RNA (EBER) has been reported to be negative.5, 8, 9 It has been suggested that abnormalities of p53 regulation might be crucial in the pathogenesis of LELC of the urinary bladder.10 Though the exact origin of these carcinomas is not well known, the expression of common urothelial markers suggest that they are probably modified urothelial cells that have derived from stem cells.5, 6