TLR4 and infection: In addition to disparities in rates between different populations and ethnic groups, three susceptible genes, ribonuclease L (RNaseL) (Rokman et al, 2002), macrophage scavenger receptor 1 (MSR1) (Xu et al, 2002), and toll-like receptor-4 (TLR-4) (Sun et al, 2007), have been associated with familial CaP and all functions in host immune responses or in host protection against cellular and genomic damage mediated by the infection itself or by the inflammatory oxidants secreted by leukocyte-infiltrating cells in response to infection.