The combined treatment of gemcitabine and B7-H3 blockade showed a substantial synergistic anti-tumour effect on pancreatic cancer (n=5, 27.1±4.9 mm3, P<0.0001 compared with gemcitabine alone or B7-H3 blockade alone) (Figure 7). The gene discussed is CD276; the disease is familial pancreatic carcinoma.