CD276 and neoplasm: Several murine studies have shown that introduction of B7-H3 in tumour cells and tissues by various methods activates tumour-specific immunocompetent cells and promotes anti-tumour response, thereby leading to rapid tumour regression, reduction of metastasis, and prolongation of animal survival (Sun et al, 2003; Luo et al, 2004, 2006; Lupu et al, 2006, 2007).