As a result, the depletion of CD8+ T cells completely abolished the effect of anti-B7-H3 mAb on murine pancreatic cancer (tumour volume at 4 weeks: anti-B7-H3 mAb, n=5, 255.4±21.4 mm3; control, n=5, 240.1±21.4 mm3; N.S.)(Figure 6). This evidence concerns the gene CD8A and familial pancreatic carcinoma.