For example, androgen withdrawal-induced marked downregulation of relaxin, VEGF, vimentin and BMP-6, involved in cancer progression (Soker et al, 2001; Dai et al, 2005; Thompson et al, 2006; Feng et al, 2007; Wei et al, 2008) as well as upregulation of cellular retinol binding protein 7 and interferon-γ receptor, negatively regulating cancer progression (Kuppumbatti et al, 2001; Yang et al, 2008), in LNCaP/IL-6#1. This evidence concerns the gene BMP6 and cancer.