In addition, expression levels of some genes associated with the progression of prostate cancer, such as relaxin, vascular endothelial growth factor (VEGF), vimentin and bone morphogenetic protein-6 (BMP-6) (Soker et al, 2001; Dai et al, 2005; Thompson et al, 2006; Feng et al, 2007; Wei et al, 2008), were significantly downregulated in LNCaP/IL-6#1 compared with LNCaP/Co. This evidence concerns the gene BMP6 and Familial prostate cancer.