SNAI1 and carcinoma: Kurrey et al (2005) reported ectopic Snail or Slug expression to result in induction of EMT in an ovarian carcinoma cell line, with enhanced motility and invasiveness, loss of expression of epithelial markers and increased expression of vimentin. Stable silencing of endogenous Snail concomitantly induced complete mesenchymal–epithelial transition in MDCK-Snail cells, and reduction of in vivo tumour growth of two independent, stably Snail-silenced carcinoma cell lines (Olmeda et al, 2007).