Upregulation of Snail mRNA expression under hypoxic conditions, accompanied by downregulation of E-cadherin, has been reported in ovarian cancer cell lines (Imai et al, 2003; Kurrey et al, 2005), and invasiveness of hypoxic ovarian cancer cell lines has also been shown to increase (Imai et al, 2003). The gene discussed is CDH1; the disease is ovarian carcinoma.