The early growth of colorectal tumours requires angiogenesis (Goodlad et al, 2006; Korsisaari et al, 2007), the consequence of increased expression of pro-angiogenic factors (e.g., vascular endothelial growth factor-A (VEGF-A); Ferrara et al, 1991; Kim et al, 1993; Jubb et al, 2003; Korsisaari et al, 2007). The gene discussed is VEGFA; the disease is colorectal neoplasm.