Moreover, the lack of a prognostic association for endothelial Dll4, a VEGF target (Patel et al, 2005), is in agreement with the lack of a prognostic association for VEGF in colon cancer in this study and elsewhere (Nanni et al, 2002; Zheng et al, 2003; Jubb et al, 2006a). The gene discussed is DLL4; the disease is malignant colon neoplasm.