Albuminuria, the main marker of structural renal injury, another component of the definition of CKD, is fundamental in patients with GF >60 ml/min/1, 73 m2, and was not determined in this study since its occurrence could be mitigated by the use of optimized angiotensin-converting enzyme inhibitors, AT1 blockers, and aldosterone antagonists, thereby inducing false negative diagnoses [37]. The gene discussed is ACE; the disease is chronic kidney disease.