BRCA1 and breast cancer: Figure 4 shows HR estimates for the 12 LD blocks genotyped in IGF1R. For BRCA1 carriers, significant associations were found between LD block 2 (SNP rs2715415) and LD block 11 and the risk of breast cancer diagnosis (unadjusted global P values corresponding to a test of homogeneity of risk within the LD blocks were 0.011 for LD block 2 and 0.012 for LD block 11).