BRCA1 and cancer: Another piece of evidence that this region may be associated with breast cancer is the association of SNP rs13387042 with a 1.2-fold increased risk in breast cancer, reported in a deCODE genome-wide association study [46] - with replication by the Cancer Genetic Markers of Susceptibility project (odds ratio = 1.2) [47], by the Breast Cancer Association Consortium (odds ratio = 1.14) [48], and by the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (HR = 1.14 and HR = 1.18 for BRCA1 and BRCA2 carriers, respectively) [49].