BRCA1 and breast cancer: After investigation in BRCA1 carriers of the individual SNPs within LD block 11 (Table 2), the only SNP that was significantly associated with risk was rs8038415 - in which individuals homozygous for the variant allele were estimated to experience a 40% higher risk of breast cancer diagnosis (unadjusted P = 0.014, with P for trend = 0.015).