The usefulness of gene trap technology to identify genes responsive to viral infections is additionally supported by the fact that the CRL gene was not identified in screenings designed to detect genes regulated during different virus infections (including CaLCuV) using A. thaliana microarrays and sDNA-AFLP analysis (AffyID 24849_at; gene At5 g51020) [25,43-45]. This evidence concerns the gene IL31RA and viral infectious disease.