Multivariate analysis revealed that a positive history of hypertension, the AGT TT genotype, the NOS3 GA+AA genotype, and a pre-pregnancy BMI of 24 or higher were independently associated with severe PIH (Odds ratios (ORs): 2.53, 1.78, 2.21, and 2.44, respectively). Here, NOS3 is linked to Hypertension.