Although each of these receptors binds mannose and related monosaccharides, they have differing specificities for oligosaccharides and for surfaces of microorganisms.1,6 Both DC-SIGN and DC-SIGNR bind high mannose oligosaccharides found on viral envelope glycoproteins and can participate in viral infection either directly by facilitating viral entry into a target cell or indirectly by presenting viruses to target cells.7–10 DC-SIGN also binds fucose-containing glycans, which can serve in recognition of parasites and in binding to T cells.11,12. Here, CD209 is linked to viral infectious disease.