NFKB1 and acute lymphoblastic leukemia: To check the impact of physiological MSX2 and oncogenic TLX1 on cell survival we treated transduced JURKAT cells with gamma-secretase-inhibitor DAPT, NFkB-inhibitor, PI3K-pathway-inhibitor Rapamycin as well as Calphostin C, which triggers calcium-dependent apoptosis in ALL cells [46].