This is especially true for Immunoglobulin superfamily member 4 (IGSF4/CADM1), Retinoic acid receptor beta (RARB) and Tissue inhibitor of matrix metalloproteinase 3 (TIMP3), all with MLL-dependent methylation profiles resembling BEX2. According to methylation-specific PCR (MSP), primary AML cells without rearrangement of the MLL gene also show a preference for TSG hypermethylation. Here, TIMP3 is linked to acute myeloid leukemia.