To investigate the role of TGFB1 and VEGF SNPs in the etiology of gastric cancer, we conducted a case-control study to evaluate the association between three TGFB1 SNPs (one promoter SNP -509C>T and two exon 1 SNPs +869T>C and +915G>C) and three VEGF SNPs (one promoter SNP -1498T>C, one 5'-untranslated region SNP -634G>C and one 3'-untranslated region SNP +936C>T) and gastric cancer risk in a US population. Here, VEGFA is linked to gastric cancer.