The mechanism of the adverse prognostic impact of VEGF-C/VEGFR3 signalling may include dissemination of tumour cells in the systemic circulation and arrest in lymph nodes/distant sites, direct enhancement of lymph-angiogenesis, and creation of a permissive environment for tumour progression by the induction of adhesion molecules, growth factors, and proteolytic enzymes. Here, FLT4 is linked to neoplasm.