Nevertheless, we can establish this diagnosis with high probability, since this patient’s Cushing’s syndrome was ACTH-dependent, with a positive result in the high-dose dexamethasone suppression test with characteristic phenotype and biochemical presentation (hypertension and severe hypokalemic metabolic alkalosis), and with a tumor type that can cause Cushing’s syndrome. This evidence concerns the gene POMC and Cushing syndrome due to macronodular adrenal hyperplasia.