PPP2CA and breast adenocarcinoma: Using breast adenocarcinoma derived MCF7 and MDA-MB 231 cells expressing different levels of Arl2, we have shown that alterations of cellular Arl2 protein content were associated with modifications of polymerization-competent −alpha/beta tubulin heterodimer levels resulting in altered MT dynamic properties and with modifications of mitotic progression as well as with modifications of the content, localization and activity of PP2Ac with no significant changes in PP2Ac mRNA levels [20].