AR and lobular neoplasia: The mean (SD) ARs for anti-nucleosome antibodies were significantly higher for LN patients than controls (means were calculated on raw data, but log-transformed data were analysed where appropriate) (0.32 [0.35] versus 0.01 [0.01], P < 0.0001) as were the high-avidity anti-dsDNA AR (0.50 [0.50] versus 0.07 [0.01], P < 0.0001) but not anti-α-actinin (0.33 [0.32] versus 0.29 [0.25]).