INS and diabetes mellitus: Thus, when there was little change in fasting glucose there was minimum change in the renal excretion of glucose and only about 10 μmol/L lower blood uric acid levels during the weight loss period whereas a deterioration in their diabetes control with an increase in fasting glucose (with probably higher insulin levels) was linked to a greater spillover of urinary glucose and the most marked fall in blood uric acid levels seen in the whole population group.