BRAF and cutaneous melanoma: Other distinct subgroups of melanoma have been shown to harbor oncogenic mutations in the receptor tyrosine kinase KIT. While BRAF mutations are the most common oncogenic mutation in cutaneous melanoma, mucosal melanomas and acral lentiginous melanomas often have wild type BRAF, but may carry mutations in KIT gene (though, the role of such alterations in melanomagenesis are yet to be clearly defined).