Moreover, several WNT proteins have been shown to be overexpressed in various human cancers; among them, the up-regulation of the WNT2 seems to participate in inhibiting normal apoptotic machinery in melanoma cells [155] (recently, it has been suggested that the WNT2 protein expression levels can be also useful in the differential diagnosis of nevus versus melanoma [156]). Here, WNT2 is linked to melanoma.