It has been reported that PTEN expression is lost in melanoma cell lines with high AKT expression, suggesting that the activation of AKT induced by PTEN inactivation or growth factor signaling activation could represent an important common pathway in the progression of melanoma (probably, by enhancing cell survival through up-regulation of NF-kB and escape from apoptosis) [85]. Here, NFKB1 is linked to melanoma.