Previous studies revealed similar data and recommended the use of this marker as a useful test to identify thyroid malignancies including FC and PTC.[16, 19, 20] Orlandi et al. and Saggiorato et al. recommended the application of galectin-3 as a useful IHC test for presurgical diagnosis of thyroid nodules that require surgical removal.[23, 25]. The gene discussed is LGALS3; the disease is thyroid nodule.