Finally, the gene-set #2 also contained several tumour suppressors (EPHA3 and EPHB2) and proto-oncogenes (AKT1, AURKA, ETV6, MITF and PIK3CA), which expands on the observed enrichment of the immune response and suggests that this gene-set has a critical role in breast tumorigenesis. This evidence concerns the gene PIK3CA and neoplasm.