It is worth noting that all of the ESR1-negative BRCA1 tumours in group A, which show low expression of NFκB, harboured truncating mutations in the central portion of BRCA1 that are thought to trigger the nonsense-mediated mRNA decay mechanism (Perrin-Vidoz et al, 2002) (Supplementary Table S4). Here, BRCA1 is linked to neoplasm.