Moreover, additional experimental studies on the complexity of the interaction between insulin-signalling systems and amyloid peptides [42] are needed to open up new possibilities for the treatment of AD and the role of antidiabetic drugs such as metformin in the modulation of the metabolism of amyloid precursor protein [43] should be clarified in order to delineate its potential harmful effects in DM2 patients. The gene discussed is INS; the disease is Alzheimer disease.