In a further study by our group a differential chemosensitivity of BRCA1-mutated HCC1937 human breast cancer cells to microtubule-interfering agents has been found [26] Quinn et al. in a similar cell system, where BRCA1 was reconstituted by a retroviral vector containing the full length cDNA and compared to parental cells infected with empty vector, demonstrated that BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis. Here, BRCA1 is linked to breast carcinoma.