Subsequently they have evaluated BRCA1 mRNA expression in 70 tissue samples in sporadic ovarian tumors from patients which underwent treatment with platinum derivatives and they found that patients with low-intermediate levels of BRCA1 mRNA had a significantly better outcome in terms of overall survival (OS) as compared to high BRCA1 mRNA levels (57.2 months versus 18.2 months p = 0.0017). This evidence concerns the gene BRCA1 and ovarian neoplasm.